JanSlezak教授一直围绕该研究所的工作任务开展研究，1976年被任命为研究所副所长，1988年被任命为所长，1998年当选为该研究所学术主席团成员和副主席，在这个位置上直到2009年6月，由于他的出色组织管理能力，斯洛伐克医科大学邀请他担任副校长。
JanSlezak教授主要研究兴趣集中在实验心脏病学功能形态学方向，尤其是关于心肌缺血、心肌肥大、非均质性和预适应等方面。他系统研究了活性氧在心脏损伤发生中的作用机制，对辐射诱发心脏病预防和缺血性预处理等也开展了深入研究。
在他的科学生涯中，先后发表550篇学术论文，10本专著和5本教科书。受到许多国际学术机构邀请在国际会议上做学术报告，先后访问大量著名学术机构。他也是一些著名研究机构和大学的董事会成员，9本学术期刊编辑委员会成员。他一直担欧洲心脏研究委员会委员和国际心血管科学院和董事会成员。由于他在科学研究和教育方面的突出贡献，被先后授予许多重要奖项。
非常重要的是，著名的JanSlezak教授已经参与了氢气治疗放射性损伤保护的研究。
9月15日他给广州氢医学十周年带来的学术报告题目是：本人有幸给他做简介。
Therapeutic applicationof molecular hydrogen in situations with excessive production of free radicals
Ján Slezák1, Juraj Surovy2, Ján Buday2,Branislav Kura1
1Institute forHeart Research, Slovak Academy of Sciences, Bratislava, Slovakia
2ElectrotechnicalResearch and Projecting Company, Nová Dubnica, Slovakia
jan.slezak@savba.sk
BACKGROUND:As a common denominator of many pathological processes, excessive production of reactiveoxygen species (ROS) has been regarded. Hydroxyl andnitrosyl radicals are the major cause of the destruction of biomolecules eitherby a direct action or by triggering the chain reaction of free radicals. Scavengingof excessive levels of ROS may result in preventive or therapeutic effects. A number of substances including molecular hydrogen, can serve as scavengers that increase thecapacity/activity of endogenousantioxidants thereby augmenting cells and tissues protection against oxidative damage. OBJECTIVES:Targetedapplication of molecular hydrogen (H2) as one of the potentscavengers may be used in the prevention and treatment of ROS-related diseases.H2 reacts with strong oxidants, suchas hydroxyl and/or nitrosyl radicals thatmakesit possible to utilize its potential for preventive and therapeuticapplications. H2 is able to reduce oxidative stress also byregulating gene expression, and acts as an anti-inflammatory and anti-apoptoticagent. METHODS: As a source of free radicals, we used radiation thatinteracts with the water present in the cells, resulting in its hydrolysis andformation of free radicals (especially hydroxyl OH). Wistar rats atthe age of 12 weeks, weighing approximately 250 g, were irradiated with asingle dose of 25 Gy (6-7 Gy / min) and/or 10 Gy (4-5 Gy / min.) targeted to the mediastinal area. Therapeuticapplication of hydrogen has been performed by different delivery methodsincluding inhalation, drinking hydrogen rich water and/or infusion ofhydrogen-saturated solutions.Concentrations of malondialdehyde (MDA) in rat serum were determined byspectrophotometric method using a commercially available TBARS assay kit(Cayman Chemical, Michigan, USA). TNF-α expression was analyzed from the leftventricle tissue using the Western blot method. Changes in miRNA 1, 15b and 21levels were measured byRTqPCR. RESULTS: Theresults demonstrate in irradiated rats a decrease in MDA and TNF-α levels aswell as miRNAs return almost to control levels following H2 administration.
CONCLUSION: H2 may be an effective and novelclinical tool for treating oxidative stress-related diseases. miRNAsrepresent potential targets for modulation and manipulation to be used asbiomarkers and therapeutic instruments.
Themissing links of how hydrogen is involved in cell signaling and activation orsuppression of transduction pathways, and how molecular hydrogen can reduceinflammation deserve special attention.
研究结果证明，各种给氢气的方法，吸入、饮用或注射氢水都可以对抗放射线导致的氧化和炎症损伤，这种损伤可以用MiRNA检测进行分析。属于会议摘要，详细研究结果请等待正式发表。
紫罗兰是紫的，红玫瑰是红的，氢是爱我们的
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记住：救护车一响，一年猪白养；住上一次院，三年活白干；十年努力奔小康，一场大病全泡汤
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